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23 New Startups in AI Drug Development Space Launched 2023–2025
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23 New Startups in AI Drug Development Space Launched 2023–2025

A snapshot of emerging startups applying AI across the drug development pipeline—from molecular design to clinical decision support

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BiopharmaTrend
Apr 18, 2025
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Where Tech Meets Bio
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23 New Startups in AI Drug Development Space Launched 2023–2025
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AI began entering biomedical research in the 1970s through early initiatives like SUMEX, which explored how computing could support scientific reasoning. By the late 1980s, applications such as MULTICASE and ADAPT introduced AI-driven tools for toxicity prediction, marking its first use cases in drug development.

Joshua Lederberg at a Laboratory Instrument Computer teletype in 1974, during the launch of SUMEX—Stanford’s pioneering AI infrastructure for medical research. (Courtesy: U.S. National Library of Medicine)

By 2022, AI-generated drug candidates began entering preclinical and clinical pipelines, moving from theory to application. COVID-19 accelerated interest in computational methods, and the release of AlphaFold showed how AI could crack complex biological prediction problems. Around the same time, transformer-based large language models—popularized by tools like ChatGPT—made AI more visible across research and industry.

Regulatory agencies are responding as well—in 2024, the FDA’s Center for Drug Evaluation and Research (CDER) formed an AI council and released draft guidance on AI use in drug development workflows.

In this article: Protein and Peptide Engineering Platforms — Model Simulation and Physics‑Based Tools — Generative and Foundation Model Ecosystems — AI‑Enhanced Drug Discovery Workflows — Multi‑Omics and Precision Diagnostics — AI‑Driven R&D Support and Optimization Platforms — Autonomous Scientific Research and Lab Automation

Today we’re taking a look at a new wave of startups that entered the AI drug discovery scene over the past two years, between 2023 and early 2025.


Protein & Peptide Engineering

Xaira Therapeutics

Location: San Francisco, CA, USA
Launch Year: 2024

Xaira Therapeutics, a biotechnology company with $1 billion in funding, is focused on advancing drug discovery by integrating AI research, data generation, and therapeutic development.

Leveraging the work of co-founder Dr. David Baker at the University of Washington, Xaira utilizes AI models such as RFdiffusion and RFantibody to design novel proteins and antibodies targeting complex biological challenges. Its computational framework covers the entire drug development process, from biological discovery and molecular design to clinical development.

Xaira’s data platform integrates diverse, high-resolution datasets to train models and generate hypotheses. It aims to reveal disease mechanisms and improve predictions, especially where existing data is limited.

The company uses an iterative pipeline that refines its models based on experimental results, helping to accelerate the development of potential therapeutics.


Abiologics

Location: Cambridge, MA, USA
Launch Year: 2024

Abiologics is a Flagship Pioneering-founded company developing a new class of suprabiological therapeutics called Synteins. These are synthetic proteins composed of amino acid building blocks beyond the 20 naturally occurring L-amino acids, including D-amino acids. The company uses generative AI and deep learning to design these structures.

According to Abiologics, Synteins are intended to overcome the limitations of recombinant protein technologies. The company states that its approach enables scalable production of ultrastable synthetic proteins with enhanced bioavailability and tissue penetration, including access to solid tumors and the gastrointestinal tract.

Abiologics combines computational protein design with automated laboratory systems to accelerate the discovery-to-validation cycle. It aims to reduce both time and cost compared to traditional biologic development. One of its current candidates is a Syntein-based GLP-1 therapeutic in development as an oral treatment for metabolic disorders.

Abiologics has received a $50 million initial financing from Flagship Pioneering to advance its platform and therapeutic pipeline.

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